PLEIOTROPHIN INTERACTION WITH SYNTHETIC GLYCOSAMINOGLYCAN MIMETICS

Pleiotrophin Interaction with Synthetic Glycosaminoglycan Mimetics

Chondroitin sulfate (CS) E is the natural ligand for pleiotrophin (PTN) in the central nervous system (CNS) of the embryo.Some structures of PTN in solution have been solved, but no precise location of the binding site has been reported yet.Using 15N-labelled PTN and HSQC NMR experiments, we studied the interactions with a synthetic CS-E tetrasacch

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Combined etiology of anaphylactic cardiogenic shock: Amiodarone, epinephrine, cardioverter defibrillator, left ventricular assist devices and the Kounis syndrome

Anaphylactic shock is a life-threatening condition which needs detailed and mediculous clinical assessment and thoughtful treatment.Several causes can join forces in order to degranulate mast cells.Amiodarone which is an iodine-containing highly lipophilic benzofuran can induce allergic reactions and anaphylactic shock in sensitized patients.Epinep

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